Milan Holecek Selected Research

Isoleucine (L-Isoleucine)

1/2016	Phenylbutyrate exerts adverse effects on liver regeneration and amino acid concentrations in partially hepatectomized rats.
1/2015	Ammonia and amino acid profiles in liver cirrhosis: effects of variables leading to hepatic encephalopathy.
5/2014	Glutamine deficiency in extracellular fluid exerts adverse effects on protein and amino acid metabolism in skeletal muscle of healthy, laparotomized, and septic rats.
3/2014	Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-therapeutic perspectives.
10/2013	Branched-chain amino acids and ammonia metabolism in liver disease: therapeutic implications.
2/2011	Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle.
5/2010	Three targets of branched-chain amino acid supplementation in the treatment of liver disease.

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Milan Holecek Research Topics

Disease

12	Sepsis (Septicemia) 09/2015 - 02/2002
6	Neoplasms (Cancer) 12/2016 - 02/2002
4	Liver Diseases (Liver Disease) 01/2016 - 05/2010
4	Hepatic Encephalopathy 01/2015 - 05/2010
4	Liver Cirrhosis (Hepatic Cirrhosis) 01/2015 - 05/2010
3	Starvation 01/2016 - 12/2011
3	Hyperammonemia 01/2015 - 05/2010
3	Body Weight (Weight, Body) 09/2012 - 10/2004
2	Inborn Urea Cycle Disorders 01/2017 - 01/2016
2	Endotoxemia 03/2015 - 09/2012
2	Inflammation (Inflammations) 01/2015 - 02/2008
2	Wounds and Injuries (Trauma) 05/2014 - 02/2002
2	Critical Illness (Critically Ill) 05/2014 - 02/2002
2	Liver Failure 03/2014 - 10/2013
1	Breast Neoplasms (Breast Cancer) 12/2016
1	Acute Kidney Injury (Acute Renal Failure) 03/2015
1	Liver Neoplasms (Liver Cancer) 01/2015
1	Renal Insufficiency (Renal Failure) 01/2015
1	Varicose Veins (Varicose Vein) 01/2015
1	Hemorrhage 01/2015
1	Brain Diseases (Brain Disorder) 01/2015
1	Brain Edema (Cerebral Edema) 03/2014
1	Acquired Immunodeficiency Syndrome (AIDS) 09/2012
1	Chronic Kidney Failure (Chronic Renal Failure) 06/2012
1	Cachexia 05/2010
1	Necrosis 10/2006
1	Acidosis 08/2003

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2016 - 08/2003
7	Isoleucine (L-Isoleucine)FDA Link 01/2016 - 05/2010
7	Leucine (L-Leucine)FDA Link 01/2016 - 02/2008
7	Glutamine (L-Glutamine)FDA Link 05/2014 - 02/2002
6	Valine (L-Valine)FDA Link 01/2016 - 05/2010
6	Branched-Chain Amino AcidsIBA 01/2016 - 05/2010
6	Amino Acids FDA Link 01/2015 - 08/2003
5	AmmoniaIBA 01/2017 - 05/2010
3	Saline SolutionIBA 09/2012 - 11/2006
3	Proteasome InhibitorsIBA 10/2006 - 12/2004
2	Histone Deacetylase InhibitorsIBA 01/2017 - 01/2016
2	Proteasome Endopeptidase Complex (Proteasome)IBA 09/2012 - 10/2006
2	Polymethyl Methacrylate (Sol)IBA 02/2011 - 02/2008
2	TurpentineIBA 02/2008 - 11/2006
1	3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) (Alpha-Keto Acid Dehydrogenase)IBA 01/2016
1	EnzymesIBA 01/2016
1	Alanine Transaminase (SGPT)IBA 01/2016
1	NitrogenIBA 01/2016
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 03/2015
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 03/2015
1	Dexamethasone (Maxidex)FDA LinkGeneric 03/2015
1	Pharmaceutical PreparationsIBA 03/2015
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 03/2015
1	Arginine (L-Arginine)FDA Link 01/2015
1	Glutamic Acid (Glutamate)FDA Link 10/2013
1	Triglycerides (Triacylglycerol)IBA 09/2012
1	EndotoxinsIBA 09/2012
1	CholesterolIBA 09/2012
1	Adrenal Cortex Hormones (Corticosteroids)IBA 06/2012
1	Caseins (Casein)FDA Link 12/2011
1	Aromatic Amino Acids (Aromatic Amino Acid)IBA 05/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2006
1	benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA 10/2006
1	CytokinesIBA 10/2006
1	InterleukinsIBA 10/2006
1	Growth Hormone (Somatotropin)IBA 01/2006
1	Guanethidine FDA Link 10/2004
1	Adrenergic Agents (Adrenergic Drugs)IBA 10/2004
1	Keto AcidsIBA 02/2002
1	Alanine (L-Alanine)FDA Link 02/2002

Therapy/Procedure

6	Ligation 09/2015 - 12/2004
6	Punctures 09/2015 - 12/2004
1	Mastectomy (Mammectomy) 12/2016
1	Radiotherapy 12/2016
1	Segmental Mastectomy (Lumpectomy) 12/2016
1	Adjuvant Radiotherapy 12/2016
1	Surgical Portasystemic Shunt (Portosystemic Shunt) 01/2015
1	Laparotomy 05/2014
1	Therapeutics 03/2014
1	Nephrectomy 06/2012
1	Cell Transplantation 06/2012
1	Denervation 06/2012
1	Subcutaneous Injections 11/2006